Ozempic vs. Contrave
Ozempic and Contrave differ in purpose and effectiveness. Ozempic is a GLP-1 agonist for type 2 diabetes and cardiovascular risk reduction, while Contrave, a combination of naltrexone and bupropion, focuses on chronic weight management. Ozempic delivers HbA1c reductions and moderate weight loss, while Contrave’s weight loss is less pronounced. Side effects differ: Ozempic causes nausea, while Contrave may lead to insomnia and mood changes. Ozempic costs $875/month, substantially higher than Contrave’s $300/month. Neither drug currently faces shortages.
Slows gastric emptying, reduces appetite, and enhances feelings of fullness, leading to lower calorie intake. It also stimulates insulin release and reduces glucagon secretion, improving blood sugar control.
Common Side Effects
Nausea, vomiting, diarrhea, constipation, and abdominal pain.
Serious Potential Side Effects
Pancreatitis, gallbladder issues, kidney problems, and increased heart rate, thyroid cancer, anaphylaxis (or serious allergic reactions)
Bupropion enhances dopamine and norepinephrine activity, reducing appetite and cravings; Naltrexone modulates the brain’s reward system, reducing cravings and emotional eating behaviors by blocking opioid receptors.
Common Side Effects
Nausea, constipation, headache, dizziness, dry mouth, and insomnia.
Serious Potential Side Effects
Increased blood pressure, seizures (rare), suicidal thoughts, and liver damage.