Qsymia vs. Orlistat
Qsymia and Orlistat approach weight loss differently. Qsymia uses phentermine and topiramate to suppress appetite and enhance satiety, delivering significant weight loss. Orlistat, a lipase inhibitor, blocks fat absorption for modest weight loss. Qsymia may cause side effects like insomnia and mood changes, while Orlistat is associated with gastrointestinal issues such as oily stools. Qsymia costs $250/month, significantly more than Orlistat’s $100/month. Neither drug currently faces shortages.
Phentermine suppresses appetite by stimulating the release of norepinephrine in the brain; topiramate enhances feelings of fullness and alters taste perceptions, reducing food intake.
Common Side Effects
Dry mouth, insomnia, constipation, dizziness, and tingling in hands or feet.
Serious Potential Side Effects
Increased heart rate, mood changes, suicidal thoughts, and memory/concentration difficulties, dependency and abuse of medication
Blocks the breakdown and absorption of dietary fat in the intestines. Unabsorbed fat is excreted in the stool, reducing calorie intake and promoting weight loss.
Common Side Effects
Oily or fatty stools, frequent bowel movements, flatulence with discharge, and abdominal discomfort.
Serious Potential Side Effects
Rare liver damage and malabsorption of fat-soluble vitamins (A, D, E, K), kidney problems, and severe allergic reactions