Wegovy vs. Trulicity
Wegovy and Trulicity both belong to the GLP-1 agonist class but serve different primary purposes: Wegovy is for weight management, while Trulicity is for type 2 diabetes and some cardiovascular conditions. Wegovy achieves greater weight loss (around 15%), while Trulicity provides modest HbA1c reductions (1-1.5%). Trulicity is also used off-label for weight management, like Wegovy. Both share common side effects like nausea, with Trulicity also causing fatigue. Serious risks, including pancreatitis, overlap. Wegovy is significantly pricier, costing $1,375/month versus Trulicity's $875/month. Both are readily available without shortages.
Slows gastric emptying, reduces appetite, and enhances feelings of fullness, leading to lower calorie intake. It also stimulates insulin release and reduces glucagon secretion, improving blood sugar control.
Common Side Effects
Nausea, vomiting, diarrhea, constipation, abdominal pain, headache, and fatigue.
Serious Potential Side Effects
Pancreatitis, gallbladder issues, kidney problems, and increased heart rate, thyroid cancer, anaphylaxis (or serious allergic reactions)
Slows gastric emptying, reduces appetite, and enhances feelings of fullness, leading to lower calorie intake. It also stimulates insulin release and reduces glucagon secretion, improving blood sugar control.
Common Side Effects
Nausea, diarrhea, vomiting, fatigue, and decreased appetite.
Serious Potential Side Effects
Pancreatitis, thyroid tumors (potential risk), gallbladder issues, kidney problems, and serious allergic reactions