Trulicity vs. Orlistat
Trulicity and Orlistat have distinct mechanisms and purposes. Trulicity, a GLP-1 receptor agonist, is for type 2 diabetes management, providing HbA1c reductions and modest weight loss. Orlistat, a lipase inhibitor, blocks fat absorption and achieves modest weight loss without affecting glucose levels. Trulicity commonly causes nausea, while Orlistat is associated with gastrointestinal issues such as oily stools. Trulicity costs $875/month, significantly more than Orlistat’s $100/month. Neither drug currently faces shortages.
Slows gastric emptying, reduces appetite, and enhances feelings of fullness, leading to lower calorie intake. It also stimulates insulin release and reduces glucagon secretion, improving blood sugar control.
Common Side Effects
Nausea, diarrhea, vomiting, fatigue, and decreased appetite.
Serious Potential Side Effects
Pancreatitis, thyroid tumors (potential risk), gallbladder issues, kidney problems, and serious allergic reactions
Blocks the breakdown and absorption of dietary fat in the intestines. Unabsorbed fat is excreted in the stool, reducing calorie intake and promoting weight loss.
Common Side Effects
Oily or fatty stools, frequent bowel movements, flatulence with discharge, and abdominal discomfort.
Serious Potential Side Effects
Rare liver damage and malabsorption of fat-soluble vitamins (A, D, E, K), kidney problems, and severe allergic reactions