Trulicity vs. Contrave
Trulicity and Contrave differ in mechanism and primary purpose. Trulicity, a GLP-1 agonist, is for type 2 diabetes management, achieving HbA1c reductions and modest weight loss. Contrave, a combination of naltrexone and bupropion, is for weight management, yielding less pronounced results. Trulicity causes nausea, while Contrave may lead to insomnia and mood changes. Trulicity costs $875/month, significantly more than Contrave’s $300/month. Neither drug currently faces shortages.
Slows gastric emptying, reduces appetite, and enhances feelings of fullness, leading to lower calorie intake. It also stimulates insulin release and reduces glucagon secretion, improving blood sugar control.
Common Side Effects
Nausea, diarrhea, vomiting, fatigue, and decreased appetite.
Serious Potential Side Effects
Pancreatitis, thyroid tumors (potential risk), gallbladder issues, kidney problems, and serious allergic reactions
Bupropion enhances dopamine and norepinephrine activity, reducing appetite and cravings; Naltrexone modulates the brain’s reward system, reducing cravings and emotional eating behaviors by blocking opioid receptors.
Common Side Effects
Nausea, constipation, headache, dizziness, dry mouth, and insomnia.
Serious Potential Side Effects
Increased blood pressure, seizures (rare), suicidal thoughts, and liver damage.