Zepbound vs. Contrave
Zepbound and Contrave differ in mechanism and effectiveness. Zepbound, a GLP-1 and GIP receptor agonist, reduces appetite and gastric emptying for significant weight loss. Contrave combines naltrexone and bupropion to target appetite and reward pathways, achieving less pronounced results. Zepbound’s side effects include nausea, while Contrave may cause insomnia and mood changes. Zepbound’s cost is $1,125, while Contrave costs $300/month. Neither drug faces shortages.
Enhances the effects of both incretin hormones. GIP improves insulin sensitivity and enhances fat metabolism, while GLP-1 reduces appetite, delays gastric emptying, and promotes insulin secretion, making it effective for blood sugar control and weight loss.
Common Side Effects
Nausea, vomiting, diarrhea, decreased appetite, and indigestion
Serious Potential Side Effects
Pancreatitis, thyroid tumors (potential risk), gallbladder issues, kidney problems, and serious allergic reactions
Bupropion enhances dopamine and norepinephrine activity, reducing appetite and cravings; Naltrexone modulates the brain’s reward system, reducing cravings and emotional eating behaviors by blocking opioid receptors.
Common Side Effects
Nausea, constipation, headache, dizziness, dry mouth, and insomnia.
Serious Potential Side Effects
Increased blood pressure, seizures (rare), suicidal thoughts, and liver damage.